A-72 Neuropsychological Functioning in Primary Dystonia: A Multi-Domain Meta-Analysis

Abstract Objective Primary dystonia is conventionally seen as a motor disorder, though growing literature indicates cognitive dysfunction among persons with primary (PWD). Here, we completed meta-analysis comparing cognition on clinical measures between PWD and normal controls. Method We searched PubMed, Embase, Cochrane Library, Scopus, PsycINFO using uniform search-strategy to locate original research control samples. All analyses were modeled under random-effects. used Hedge’s g bias-corrected estimate of effect size. Between-study heterogeneity was assessed Cochran’s Q I2. Results The initial search strategy yielded 866 results. Twenty studies analyzed (PWD n = 739, 865; 254 sizes extracted). Meta-analysis showed significant combined size across all (g −0.55, p < 0.001), low (Q 23.60, 0.21, I2 19.49). Trim-and-fill procedure estimated 6 missing due publication bias (adjusted −0.47, 44.58). Within-domain effects were: Motor/Non-Motor Speed −0.76, Global Cognition/Orientation −0.65, Language −0.62, Executive Functioning −0.50, Learning/Memory −0.46, Visuospatial/Construction −0.44, Simple/Complex Attention −0.36. Heterogeneity generally within domains. Effects comparable tasks −0.85) without −0.80) component. Meta-regressions indicated age, education, gender, disease duration not related sizes. Conclusions consistently demonstrated lower performances neuropsychological tests compared Effect moderate in strength, smallest Attention, largest Speed. Within the domain, results suggested slowing beyond from symptoms. This quantitative summary that experience difficulties multiple aspects cognition, detected by tests.